Roma will win against Lecce it's almost certain, even if Lecce plays at home it will be a piece of cake for them to beat them, let's remember that Roma is very well placed in the standings and with a coach like Ranieri they can really make the difference in this final part of the championship
A better ranking in the standings does not guarantee a team can always win when facing a team in a lower ranking like Lecce, because a team like Lecce can also make a good performance that can cause the final result to be beyond many people's expectations. Although before the match started almost everyone might have tipped Roma as the winner in the match, but unexpected results are always possible to happen in the match.
With the current improvements on Roma's team, I don't think that Lecce should be a problem to them because they know how to maneuver their way to victory, no matter how stubborn Lecce will prove to be. Roma should be able to get all three points in this match, buf if they underestimate Lecce and play with full assurance that Lecce is weak, they might be disappointed.