Roma will win against Lecce it's almost certain, even if Lecce plays at home it will be a piece of cake for them to beat them, let's remember that Roma is very well placed in the standings and with a coach like Ranieri they can really make the difference in this final part of the championship
A better ranking in the standings does not guarantee a team can always win when facing a team in a lower ranking like Lecce, because a team like Lecce can also make a good performance that can cause the final result to be beyond many people's expectations. Although before the match started almost everyone might have tipped Roma as the winner in the match, but unexpected results are always possible to happen in the match.
It is undeniable that in football anything can happen, and rankings cannot determine victory. However, after AS Roma was eliminated from the European league, they will pursue the European competition zone. So Roma has a great chance to win over Lecce, especially if you look at the head to head record. Plus, Lecce is currently in a poor performance trend, they have not even won in the last six matches in Serie A, of course this will be capital for AS Roma to steal points when visiting Lecce's headquarters.
AS Roma is currently in seventh place, with a collection of 51 points. Roma has a two-point difference from Lazio in sixth place, and is three points behind Juventus in fifth place. So I think Ranieri will take this opportunity to continue to improve the standings, he is aware that this is AS Roma's remaining hope this season after they failed in various competitions.