For Manchester united to beat Lyon in this quarter finals is going to be a very big deal for them, because Manchester united is not in condition they are find it difficult in times of securing victory. Although sometimes they normally surprises their fans, but one thing I believe is that if Manchester united finally wins Lyon in this game, I think they most likely qualify to the final.
I'm very sure that Man United is possible to beat Lyon. Man United performed well in UEL, they have enough players to play against Lyon. It is true that there are some injured players, but I think it won't be a problem for Amorim. Lyon is also not a very big team in Ligue 1, Man United has enough quality players to eliminate Lyon. Even if it will be a tough match, Amorim should have the way to deal with Lyon tactics. For the international match, Amorim looks better during he is managing Man United. So, I'm confident about Man United defeating Lyon.
Definitely, United should be able to win Lyon hands down both home and away. Lyon is undergoing some challenges in the club and that will affect their performance. United is becoming strong recently and if they play in their best form, victory is sure for them. I just hope they don't mess things up and disappoint their fans.