Lyon might be tough when playing other clubs but I don't think that their toughness is a problem to United. Manchester United is a team that when they are serious to win an important match, they do put in their best to make sure that they achieve victory. EPL matches might not be important to Amorim because he is using it as an experiment to know what strategy fits the players on ground. That's why you see him changing players to play in different wings and positions. However, this is an important match which Amorim knows he needs to win. He will definitely use his best winning strategy and players.
There are still 10+ days until this game is played, so we have no idea what is going to happen. First of all, we need to make sure we know who is injured or tired or whatever, to know the team that will play, is like half of the betting. Because there are moments when one team looks a bit better, but then you do not realize one of the most important players is injured and won2t play. This is why it is always smarter to bet on these games just few hours before the game.
Usually about 6-7 hours before the game the squad is known and then you can gamble on it. These two teams are too close to each other to call, and there are games between today and then, so we need to wait and see who will be playing and who won't be playing.