PSG should be able to qualify against Aston Villa. If they could qualify playing Liverpool, I don't see Aston Villa as a challenge for them. I believe they should secure a win both home and away against this said team.
Although PSG has been able to hold Liverpool from qualifying for the next round in the Champions League this season, it does not mean that we should equate Aston Villa's condition with Liverpool when Aston Villa faces PSG in the quarter-finals of the UCL this time. Because the condition of the team's strength in the Champions League is always difficult to predict, especially after the break in the last few days, there must be more changes that each team gets when they return to a big competition like the UCL. So PSG must remain vigilant against Aston Villa even though today PSG won big in Ligue1 at their opponent's home.
PSG have no pressure ahead of the game against Aston Villa, now very secure at the top of Ligue 1 with a huge points gap over their rivals. Luis Enrique could rest some key players in Ligue 1 in preparation for Aston Villa. While anything is possible in football, PSG current situation is far more favorable than Aston Villa.
The victory over Liverpool also became a motivational booster for them to again eliminate the EPL representatives.