I'm very sure that Man United is possible to beat Lyon. Man United performed well in UEL, they have enough players to play against Lyon. It is true that there are some injured players, but I think it won't be a problem for Amorim. Lyon is also not a very big team in Ligue 1, Man United has enough quality players to eliminate Lyon. Even if it will be a tough match, Amorim should have the way to deal with Lyon tactics. For the international match, Amorim looks better during he is managing Man United. So, I'm confident about Man United defeating Lyon.
Yes, you are right that Manchester United has more qualified and more expensive players than Lyon. But that cannot be a definite reference that Manchester United will win in this match against Lyon. Because as we know now, even though Manchester United has a lot of expensive players, in reality it is not able to make Manchester United have good performance. That is why if the prediction of this match is based on the depth of the squad, I think it will be a little less effective. Because the proof is that even though Lyon only has ordinary players, their performance is good. The proof is that in its domestic league Lyon is able to compete in the top 4. While Manchester United must fight in the top 15 in its domestic league. That is why I personally will not conclude specifically about the prediction for this match. Because in my personal opinion this match will be quite surprising for all of us. So the point is that Lyon could dominate the match or vice versa. So maybe the right thing we can do right now is just analyze the possibilities and narrow down our predictions. But if you want to be simpler, I think we should watch this match first, at least 7 minutes. Because with this, of course our predictions will be a little more accurate.