Right now we can not actually tell for sure what will happen because sometimes form doesn't really matter, just imagine a club like Real Madrid whether they are inform or not and they manage to find themselves in the semifinals or finals, they will always do wonder and I don't know how they use to do it but it has become part of them. Manchester united and Lyon are not consistent but I think Manchester united have more experience than Lyon and Maybe the experience might help them qualify if they actually do well.
The experience we are believing Manchester United has got isn't with the current set of players and coach too, so I don't want to bank on that as a point enough to believe Manchester United can actually win based on experience, looking at this squad, it's the first time of their coach in an europa league game and some of the players are actually experiencing their first europa experience at Manchester United this season, so there may be no much experience to bank on except for their domestic league experience of which they are fortunate to play in one of the best domestic leagues in the world.
Despite having one of the worst season in Premier League they are still doing good and achieving good results in Europa League which is giving them some good encouragement even mostly are not experienced for the big games, but their performance is telling how they are going to do Amorim is until now worst but still he is handling things fairly.
Lyon vs Manchester United is going to be challenging for both with both are looking for good end while Lyon is doing good job in French Ligue 1 chances are high for them to have another European competition in next season even they are inconsistent like Manchester United. Manchester United is now having only one option, and they will be done as much they can for having their best with this situation all will be not easy for both sides but usually here Premier League teams are much stronger and skilled for having wins.