That’s a really important point. It’s true that self-hosting your bitcoin comes with the responsibility of keeping your seed phrase safe. I think it’s crucial to have multiple backups in different locations, and even consider storing a copy in a safety deposit box or with a trusted friend or family member. It's also good to use a hardware wallet for extra security.
With this point, safest way would be to keep your ledger stored in a water and fire proof container, away from your seed phrase. Also, keep the seed phrase in a similar container,on a different location.
Actually, you know what, keep the seed phrase secure only, ledger is just a tool and is worthless without the seed