Personally, I do believe Lazio is in for a shock exit. That FK Bodø/Glimt win might have looked like a fluke but it will help build their confidence ahead of the second leg and there is nothing dangerous like an underdog that has nothing to lose when it comes to those European competitions.
Also, Manchester United have to be careful, it's not going to be a walk over even at home. For Tottenham, I predict that they are going to exit.
As I predicted before, MU will maintain a draw if they cannot win against Lyon. By bringing 2 away goals, MU can play more confidently in the 2nd leg. Of course we cannot forget how MU's performance this season was so bad, with the status of the holder of the most EPL titles, being in 13th position, making them likely not to be able to go to UEL next season. So, this season they must be able to win if they want to go to UEL, of course this is a very difficult target for MU.
Lazio is beyond my expectations, although I have predicted the confidence of the Bodo/Glimt players, but winning 2-0 over Lazio is far from my prediction. In the 2nd leg, Lazio does benefit from them being the host, but a 3-0 victory will be very difficult.