The match is going to be very tough and interesting. This kind of game is not always easy to predict because Atlético Bilbao are in serious form, and Manchester United are also doing great here in the Europa League. With that, I can't confidently say which team will win the match based on both teams' performances in the Europa League.However, looking at their domestic league performance, I might be a little more convinced and say that Atlético Bilbao is the favorite team to win this match, and I’m confident enough in that assessment.
If I were to predict further, I would say that each team might win their respective home game, as that seems to be the only way I think Manchester United can beat Atlético Bilbao. However, winning against Bilbao in their home game is something I can't confidently say, as Bilbao have a strong defensive line. For Manchester United's players to break through that Bilbao defense, it’s going to require a great effort.
Manchester United are really helpless in the domestic league, they are really bad. Not clinical, can't take advantage of clutch moments, too careless in defense. Manchester United in the domestic league always have problems or bad luck that makes them not win so they are consistent and inconsistent. However, it is understandable because Manchester United has no motivation in the domestic league because to pursue the European zone is far away and the relegation zone is also safe.
So in my opinion Manchester United's performance cannot be seen from the domestic league because they are no longer motivated, for them only the Europa League title can save them this season. The first leg of course Bilboa is very favored because they play in front of their own supporters, and of course they want to pursue victory for capital in the second leg. Amorim understands very well what to do in this match, he certainly doesn't want to be reckless by playing openly in this match, he will definitely rely on counterattacks. This match is fierce, so my prediction is that this match will not have many goals.