They will not do that unless they learn from their losses.
The ideal stoppage is when they have nothing left and they'll not do anything to stop when they still have money left.
No one can beat them and so the casino will do it for them. realization is hard and they should make themselves aware of that before the baddest situation comes.
You shouldn't even think about beating the casino, this shouldn't be the goal for players, the most important thing is to win, you shouldn't evaluate gambling as a rivalry with the casino, because the casino will always win. We will only compete with other players in some games, like poker, and in other respects it remains important to simply not get carried away too much and not spend more than you planned.