My speculation is that the Madrid match will be easier to get 3 points. Compared to Barcelona, who will need to maintain the stamina and physicality of their players, who currently have an important schedule in the UCL. On the one hand, Barcelona have had difficulties with draws in the UCL. Surely, this weekend's match could produce surprises, depending on whether the main players appear early.
Real Madrid just need to focus on La Liga and this is an advantage for them. On the other hand, Barcelona has an important match against Inter Milan. The previous UCL match also made their stamina low. Celta Vigo is a team that almost made Barca draw last week. They will probably have the same confidence when they play against Real Madrid. But we know Real Madrid always gets lucky in the last seconds of the match. And Barcelona should be able to beat Valladolid easily but the problem is that sometimes Barca's performance in the League is unpredictable like their previous match. So I think Real Madrid will win this match but I think Barcelona will struggle and maybe the result will be beyond our expectations.
We know that Madrid is always lucky in the last minutes, but they don't seem to have the capacity to do that this season, or they don't have that kind of luck. They will focus on the league, there is nothing else to do, they were eliminated early in the Champions League. Barcelona squad depth is so sufficient, I don't think their struggle with Inter in the Champions League will affect them too much, in other words, it will affect them little.