Our different targets will determine how aggressive we choose to invest and once you have achieved your investment target I think you should consider securing some profit to help reduce the risk of exposure to market volatility as risk management is also an important part of investment and one of the qualities a good investor.
As for me I don't think investing and accumulation ends, even after achieving my investment goal and probably taken profit I will just have to rebalance my portfolio and set a new target probably higher than the previous one and accumulation continues.
At that point some would consider diversifying into other investments. Our goals are different.
Targets are different for each person in question: some cash out earlier, some - they wait for other opportunities, but everybody should be certain that with BTC, any goal is reachable

Selling your bitcoin too early isn't a good way to preserve the compounding value of your bitcoin portfolio even though you have reached your bitcoin target. It's good that you continue hodli and grow your bitcoin investment portfolio overtime rather than been too eager to take profits. This is the main reason why profits shouldn't be our target in the beginning of your bitcoin portfolio till we have reached our desired bitcoin accumulation target. Bitcoin investment is for the future so why the rush to end your accumulation period early when you can still keep on growing your bitcoin investment.