Betting on an uncertain league makes more losses due to the lesser known team factor, not knowing the competitive atmosphere between teams so we can bet based on instinct. While betting on the very common top European leagues, we will better understand the situation and condition of the team's strength. So my advice is not to bet too much money on less popular leagues even though the odds are very high but the risk of losing will be closer.
When you bet on matches in small leagues and you don't know about those clubs, teams and players, you are truly gambler and actually gamble with your money. You can say you make bets based on given odds and latest forms of two clubs but those things are not enough. Understand about those clubs, their players and coaches are very fundamental for your consideration before making bet with money.
If you consider betting like trading, and you want to get profit from it, you must be very disciplined enough to ignore too risky matches. You don't need to bet in all leagues and especially leauges and matches you don't understand. There are many matches each week from top leagues in Europe and you will have many chances for betting. Just wait for a while, some days, there are more matches for betting, it's not too challenging practically.