I haven't lost significant amounts in gambling that I would regret but I have lost huge money in other ways which I do regret (..and I don't think I have to explain it here, cause that would be irrelevant to the sub).
...If possible, give us more specific advice on how to gamble without losing a large amount.
Gamble with amount you can afford to lose, or more like, consider the amount you are going to use for gambling already lost, that way you'll be detached from results.