Guys do have to figure out these kinds of matters for themselves, and I can see why someone who had been building up his bitcoin investment for 4-10 years or longer may feel like he wants to take some profits, and he might even get excited and sell too much too soon, such as selling 25% to 50% of his stash or more, but then if he really reflects on the power of bitcoin, he likely should be able to figure out some sustainable withdrawal systems that are either price based or time based that will end up resulting in his being able to continue to withdraw bitcoin yet to also be able to allow his bitcoin to continue to grow in terms of its dollar value (so he ends up largely sustaining most of his BTC stash, but still withdrawing from it on a fairly regular basis).
In other conditions, If Someone who has the ability to withstand emotional pressure and understand the basics of the coins he holds, I am sure he will be able to manage to Enjoy the Results and not lose the Long-Term Growth Potential. Yes. Quite interesting. I also recently saw a wallet that has been active for a long time, let's say he has stored 300BTC 5 years ago, well, of course this will also cause a little dilemma / desire to realize a little profit to enjoy of course with full consideration as I said above.
For someone that has probably accumulated 300 bitcoin for five years like the instance you gave, taking out profit is not out of place even though we know that in reality, not many of the people under this thread can boost of holding such a substantial worth of bitcoin. But if you've accumulated such either in the past when getting a bitcoin was easy or you did the DCA and got to this point, you're probably at your fuck you status which means that deciding to take out some chunk of BTC for a personal needs won't be totally out of place as it can also be a means of motivating yourself to keep invested even though you've attained a certain level of profit as an investor.
Emotional pressure mostly affects those at the early stage of their investment but once you've grown past that stage and can comfortably boost of owning a good amount of bitcoin, the experience you've gathered along the way will be all you need when your emotion set in to compel you to making a decision that wouldn't be favourable to you as an investor most expecially the one that really wants to make it well in the long run.