If stablecoin become a really big thing with hundred trillions dollar of market cap and there are large adoption of stablecoin pushed by governments, for sure defi will be a big thing.

It basically depends on how the adoption gonna happen to crypto, if adoption didn't increase, so does the adoption of defi to replace the tradfi.
But I can see defi becoming the future of finance, no more middle man that takes big chunk of value for nothing.