Thank you for your response, but it is too generalized to answer the question.

Lets dig a little deeper, what electronic components will fail first and why?

Are there any components inside the PSU with some kind of insulation, so that external cooling will not help?
Are there any components with electron diffusion and/or rapid material aging, which will finally lead to failure?
Are the some side effects regarding the software or control units?
Are there any other harmful side effects i do not know yet?