I've never targeted large multipliers when gambling; the odds are very low, and I've always found them to be a waste of time and money. But when it comes to betting, there's no such thing as impossible. I've witnessed people achieve 1000x multipliers, but it's not very common. If someone achieves 1000x multipliers more than once, they should start increasing their bets.

They shouldn't use such luck on small stakes. I'm a bit unlucky in this regard, so I'll stick with smaller multipliers. Who knows, maybe I'll get a shot one day.