What I used to do once I hit a big multiplier in a slot game is stop playing, if I want to continue playing, I will switch to other slot game. Most of the time I'll stop because what I believe is that when a big multipier is coming to me, that's what the best for me and I will not get better multiplier if I continue playing the same game. In specific case such as participating in a tournament where I have to play the game, I'll keep on playing the same game for the tournament especially if I feel that I have good chance to win the tournament with the bankroll that I have.