For the main event we might game same scenario that was in Whittaker vs Aliskerov. It was an early notice for Aliskerov, but he also had good record, was on a series of wins (most of them finishes), looked like a promising prospect, has Dagestani DNA

However Whittaker beat him mostly due to experience. Caught punch, dazed and finished in first round. I think odds are fair.
Reinier de Ridder has nice reach advantage in this fight against Whittaker, and that might be crucial for him to win.
He was very dominant in his previous UFC fights and I am expecting to see something similar in this fight.
If someone asks me for safest bet in main event, I would say that is fight not go to distance, but odds are very low for that.
https://sportsbet.io/sports/event/mma/ufc/ufc/robert-whittaker-vs-reinier-de-ridder-001079788e00000000000000The contrarian me speculates that this will not reach the decision because this fight will finish longer on round 5. The opponent of