The only way one may not be affected by offline gambling is when you set your rules and stick to them, but it is unfortunate that most gamblers don't even have any rules in gambling, and they can be influenced to get addicted to gambling.
There is no rules for most gamblers. Even we say that we're going to stick to our very own rules, it won't be obeyed by the most of us and that's because the situation is changing when we're already there and become emotional.
Having a good understanding and setting a rule, you can gamble whether online or offline without any negative effects. It is rules that make gamblers who they are without being changed by the gambling environment.
I doubt that there won't be any negative effects. Some might not have but the majority will have that negative effects whichever we choose to gamble. If it becomes too much, we do some mistakes that comes along whenever we gamble both offline/online.