If Alexander Isak does leave Newcastle, it would be a bad end to their relationship considering he has been so adored by their fans in recent seasons. As I know Isak actually didn't have a big desire to go before, but everything changed when the supporters started hating Isak and labeled him as a rat, and after this situation, Isak realized that leaving was the only way for him.
The Premier League has just started, but Newcastle have a tough problem to face, because most likely Isak doesn't want to play with them anymore, and to solve this problem Newcastle must get the signature of a new striker, but unfortunately Newcastle did not have good luck in the transfer window this season.
Isak's decision not to join Newcastle United for the opening match of the season will undoubtedly complicate the situation, meaning he has no desire to remain with Newcastle United. Howe has even revealed that Isak's situation remains uncertain, making his chances of staying very slim, and he is likely to choose to leave in this transfer window.
I feel that if Isak fails to find a new team before the transfer window closes, he will lose his starting spot, having been branded a traitor. We will see this drama unfold, as it did with Osimhen, but I hope Newcastle will find a way out for players who no longer want to be with the club, and they can raise the funds to buy other players.