Honestly there aren't many interesting games on the opening week of the season.
The attention getting one is Como vs Lazio to me.

Como is working on a new project with Fabregas. He didn't even want to sign for Leverkusen this summer. They are investing in some nice young players lately.
Lazio on the other hand hasn't made big changes. In a game Como are favoured by bookies, which one do you favour? I think Como won't lose.

Como has indeed made some signings, but I still see Lazio being able to get a good result in this game, knowing that Lazio will be playing away from home, so getting a win or a draw is already a good result. Historically, Lazio has done much better when they play against Como, as you can see:
https://livescores.biz/h2h/como-vs-lazioComo has often conceded a lot of goals when they play against Lazio, but in the last game in which both teams faced each other things were different. Como did not lose and did not concede many goals, they managed a draw, this is probably due to the squad having improved in quality, so betting on Lazio's victory is risky without watching the game, that's why in the first round of Serie A I will not place a bet, I want to see all the games to know how each team is doing.