Assuming that all hardware wallets are gone, then we can technically transfer our BTC to exchanges.
I think an experienced user will just use Electrum or something else to manage their coins instead of relying on an exchange. It's such a start to move from a self-custody option to a centralized platform like that. Not to mention if HW is gone for whatever reason, then there's a higher chance that the platform is using software that has questionable security, too. If they use Electrum or something similar, then why would we have to rely on them instead of securing our wealth ourselves?