In this season, with appearance of Xabi Alonso in Real Madrid and his potential ability to improve Real Madrid considerably, Barcelona will face with bigger challenge from Real Madrid in La Liga. Therefore, every match in this season with whatever opponent is truly important for Barcelona. They must to earn maximum points as possible and avoid dropped points as least as possible. Real Madrid with Xabi Alonso management will be able to take advantage of dropped points from Barcelona to take over La Liga title.
Honestly, Barça has good squad depth, but mentally, they often lose focus against 'weaker' teams. Looking at Madrid's style of play, they don't care whether it's good or bad, as long as they get points in every match, and that's where Madrid usually excels.