Venezuela knowing what's at stake in that game are expected to go all out for a good result but playing against an Argentina side that's ranked as the no.1 team in the world, I don't think they'll be able to leave with a point from that game. Argentina leads the group just like you rightly said are surely gonna feature in the next edition of the FIFA World Cup why their opponents will need a good result to still remain in a good place to qualify but that doesn't mean Argentina will let them get a result in the Argentine soil. My prediction is that Argentina will win that game with at least 2-goal margin.
Yes, in my opinion, the Argentine team is the super favourite to win a lot more, it's also true that this will be Messi's last year, the last tournament for one of the greatest players ever, who knows, maybe he'll repeat what he did at the last World Cup, bringing them another cup.