I will always say it that once you have something huge tangible beyond your wager then just cash it out. The cashing out feature is two sided though but the casino will always payout anyways just that they benefit more if the game later comes in for you. Nevertheless , if you hit a huge win with the cash-out  open, don’t think twice just do it  ..part of the win can be used to win multiple bets than just losing it at the end