The Manchester derby is most anticipated game for eye service only in GW4
After watching international games any game in PL is much anticipated for me 
That being said this Manchester derby has a potential of backfiring spectacularly. Nobody will want to loose this one and that makes a boring game sometimes.
Any team can win the game in the upcoming Manchester derby, the reason why I said that is because both teams are not doing well in their last three matches, Manchester United even have a good performance than Manchester City, Manchester City have lost two games in their first three matches of the season, I will not say Manchester United will win Manchester City because Manchester City will be playing at home and they are very dangerous when playing at the Etihad stadium.
Manchester United's performance is not good to determine whether they can defeat Manchester City. The match will be very interesting to watch because it will be a tough match with both coaches determined to win by any means necessary, but Manchester City has home advantage and I believe they have a better chance of winning the game.