Dembele's absence will undoubtedly be felt, but Paris Saint-Germain has such a deep squad that they can fill his void. They're a fantastic team, and even their substitutes are performing brilliantly. That's why, even if a key player gets injured, they can easily replace him.
Dembélé has a history of recurring injuries → this could frustrate him. Enrique can help by maintaining the player's confidence, giving him space to slowly reintegrate into the squad after recovering. Enrique should have other options available. For example, PSG still has wing options such as Barcola, Asensio, Gonçalo Ramos (who can shift positions), or even a more offensive wingback scheme. They could also change their own game tempo, such as building up faster from the midfield, making more crosses from the fullbacks, or creating a false winger, and using a creative midfielder on the wing to keep the attack alive.