The question is, where do you store the wallet.dat regardless of how it works internally. Because this issue still exists.
Backups 
I have more data I don't want to lose. I use rsync to copy it to one of many different backup media.Especially for larger data, rsync seems to be the only reliable (and fast) way to do it. Drag & Drop, or cp and mv don't work as expected.
In terms of storage type, what do you prefer?