Goodbye GPU mining in general. I'm skeptical if you could create a new coin, just using a non-asic (yet) algo and make it a success. Dogecoin was a fluke, that aside- everything else just doesn't look like worth the effort compared to improving bitcoin itself.
Primecoin maybe? Protein folding coin?
I'd say check out monero. It's got a new codebase--not a bitcoin clone.