As far as I know no one has been able to easily compile and get this to run on OS X natively. However, you can run the miner (unfortunately without ufasoft's sse2 optimizations) using the following steps:

1) Install MacPorts (here:http://www.macports.org/install.php). This software will allow you to easily install various linux packages on your Mac.
2) Open up the terminal, and run 'sudo port -v selfupdate' to get the latest package info and then 'sudo port install wine'. This will install wine, an application that will let you run windows programs.
3) Download the windows installer of the miner (from here: http://bitcointalk.org/index.php?topic=1925.msg24217#msg24217) and unzip it. Run it in the terminal with 'wine cpuminer-installer.exe' and make sure to choose a directory you will remember (I just made one on the desktop). If you aren't sure the full path to cpuminer-installer.exe, just drag the file from the finder window to the terminal window and terminal will add it.
4) Run the miner in the terminal with 'wine /yourdirectory/minerd.exe --help' or with whatever command line options you decide. I found the cryptopp_asm32 algorithm to give my MacPro the highest hashing rates.

Happy mining.