I've noticed that withdrawing a large amount of coins from the exchange takes AGES compared to withdrawing a small amount. Sometimes, it even takes more than a day for a withdrawal request to be registered in the blockchain. And while the withdrawal is Pending to be Processed, the coins are nowhere to be found. No coins in your account, no transaction in the blockchain. So during the time your withdrawal order is still pending (this could take hours for large amounts) the exchange could be doing anything with your coins. If they weren't using fractional reserve, then there's absolutely no excuse to delay orders that much. We've yet to see a proof by cryptsy that they're not running of fractional reserve. Because if they do, they could go bankrupt at any time with all this intense trading in their exchange. Could cryptsy be the MtGox of altcoins?
I think this points more to a thorough checking process for transactions over a certian, in this case larger than average, transaction request. Wether it be awaiting human approvals or access to a cold storage wallet, I feel it hints at a more robust checking system.
Cryptsy could always re-inforce their image by explaining why it takes that length of time...