It's now possible to make wagers on events and CFD's on stocks without relying on third-party escrow, directly on the Bitcoin Blockchain using the Counterparty protocol.

XCPfeeds.info is an informational resource as well as a simplified GUI interface for making these transactions.

The livenet version still has a couple days to go but you can try it out the testnet version here: https://test.xcpfeeds.info/

Also featuring a BIP32 wallet with BTC/XCP support (compatible with your other testnet BIP32 wallets).