Sure. Let's have a 0.1 BTC bet. You bet on your desired difficulty at the end of June and I win if it's less and you win if it's more.
If the bitcoin difficulty is more than 300 billion at midnight on June 30, 2015 - I win.
Otherwise - you win.
Escrow? winner pays?
EDIT: accidentally a word
So if the difficulty is equal or more than 300 billion you win. If it's less than 300 billion then I win. We have a deal! Winner pays 0.1 BTC to the loser.
I will accept any escrow even if for this low amount I don't think it's needed.
Just for the record. RoadStress never put up his end of the bet. He seems to have fallen off the face of the earth - maybe trying to get a refund on his SP30 pre-order(s).

That's because I had to leave and didn't have the time to send. You got a PM with the txid for the 0.1 BTC.
It was the weekend - i expect roadstress will back up his bet.
personally, I would guess that difficulty on June 30, 2015 will be about 420 Billion. I think we will hit 300 Billion about 1.5 months earlier
You were correct. I was away for the weekend and yes I think that I may lose this bet. I should have pushed for May 31 2015 as deadline.