Just talk to your bank ahead of time before you send the deposit.  Make sure to ask them about their policy on any holds for large wire transfers.  Any deposit over $10k requires the bank to send a report to the IRS but that won't get you into trouble as long as you declare that money as income and pay taxes on it at the end of the year.

Honestly you're more likely to run into problems with the bitcoin exchange than you are with your bank.  I don't know if it's been sorted out now but I remember reading a few months ago about how Bitstamp was trying to make sells "prove" the source of their BTC before they would allow them to withdrawal USD.  IIRC they let them exchange the BTC into USD (and took their fee for doing so) and only notified them of the "prove your source" requirement after they had initiated the USD wire transfer.

Once you get the money out of the exchange I doubt you will run into many problems (check with your bank first anyway just in case.)  Once the bank recieves the wire transfer in your name they're legally obligated to give you that money (as long as its rightfully yours.)