Monero seems to be where the smart money is in anonymous coins. No premine, instamine, or other silliness. It's very user-unfriendly now, but that lack of user-friendliness is just more upside for those willing to invest now (Investing 101!). I'm considering it myself, but can't find a way to make a cold wallet. May just trust bter.com or other exchange with the coins until I can figure out how to make a cold wallet without messing with the client.

Note, however, that any altcoin is subject to the spin-off technique, which is likely to start happening very soon so make your money in alt-ledgers while you can