Yep. Without overclocking (since this PSU has only 2 PCI-E 6+2 pin connectors). But if you obtain two molex-to-PCI-E(6 or 6+2 pins) adaptor, you'll be able to overclock your S3 too. But do not expect too much overclocking, 'cause this PCU can provide maximum 456W power at 12V line.