I am a bit partial because I wager 2-3 btc per game sometimes up to 5 btc and have found www.BetcoinSports.com to be the place for me.  I also like a full gaming experience with blackjack and poker.  I also wager at Nitrogen from time to time. 

I recommend using a private wallet, not a wallet on an exchange and purchasing btc from localbitcoins or any exchange and then sending that to your private wallet.  Then send the btc from your private wallet to a wagering website.  When you win, send it back to your private wallet and when you want to cashout send it to an exchange such as coinbase. 

There will be no issues with this.  Let me know if you have questions.

BetcoinSports.com starts players at 2.5 btc per wager and you can request higher wagers.  My current max is 5 btc, but I did 10 btc on the Superbowl...to my Denver dismay.