You'll need to pick several big winners back to back and re-invest your profits.

If first coin goes x10 then you make 10 btc
Second coin goes x5 then you make 50 btc
Third coin makes x4 then you make 200 BTC

That's risky though re-investing all your profits into one coin. Once you have 10 btc, it's better to spread your bets amongst several promising, cheap coins.

The only coin I ever made >100x return was on Litecoin because I bought it when it was a few cents. The problem is now any coin that is promising is given a high valuation immediately.

Also don't forget the bigger the amount of money you have the harder it is to make a huge gain. You can't put 50 BTC into a coin that has a 200 BTC market cap.