The laws of physics change may or may not change depending on cosmological factors we are only beginning to observe (EG fine-structure constant). 

More importantly, our understanding of those laws change continually and sometimes rapidly as they evolve in punctuated equilibria.

Source: http://en.wikipedia.org/wiki/Scientific_revolution

We don't have a grand unified theory, so the laws have to change if we are to accommodate one.

Did you sleep through the Copernican Revolution?

Where you out sick for the Bohr–Einstein debates?

Please fuck off with your smug absolutist Debbie Downer negativity. 

Innovation will proceed, regardless of your pitiable lack of imagination and optimism.