Another problem you would have to figure out is how you would even use the said exchanges without java,flash,etc, and using the machine at all if everything is stored to RAM. You are asking for a bulletproof system, and nothing will ever be 100% secure, nothing.

So, your best bet is to set up a Liberte linux or Tails, or some other live distro (minimal) with persistent data on a USB for your exchanges and such and an offline system/wallet for your funds (unless you have a massive USB drive for the blockchain data) even then, you will need to have copies of your .dat file, because you are at more risk of dropping the usb drive or a failure with it, to destroy your life then you are from using a linux distro, dual booted on your pc, and those "infected" computers around you. Which IMO, is not a risk at all if you have any common sense .