Imho for gameplay it's TS better for easy room management, etc. Skype is ok for everything(even it doesn't excel in anything specific).

But what is imho great project that you can use as you like is Mumble http://wiki.mumble.info/wiki/Main_Page . It enables the both Skype and TS(from what I know) and as a great addition is encryption while it's ----- wait for it ----- Open source.