Not neoscrypt, regular scrypt and scrypt-n!
I said "NScrypt" incorrectly when I ment scrypt nfactor, sorry.

I have been away from altcoin business too long.

But for scrypt, the difference is obvious.. 13.11 bin gives about 800kh/s on my 280x, and 700kh/s if compiled under 14.6, from the same source.
Always backup your bins when upgrading Catalyst, then you can try each version. Only compile time matters, there usually is no big difference what version Catalyst you are using at runtime..