With such an ammount i would find 1 or 2 coins you really like. Make a list with all the coins you like. Remove all you can over time, research research research and make the list smaller. You can list some for some later buys and choose 1 or 2 for your investment right now. I would go with Substratum and Dragonchain if i only could buy 2 right now, but i guess we all have different opinions on that one.
My first buy was actually those coins in ICO's and in the last bull season i sold some and bought a lot more coins from my profit and now bought some back cheaper so i still have the same ammount of those, but also a lot of other coins. I still have a long list with coins i want to buy but we can't have 'em all. :/
GL out there! I really believe that almost no matter what we buy if we just hold a year or two, we will have a great ammount of money. (unless that project died :-D)