One day the SEC or some other US government apparatus will crack down on an exchange with the official reasoning that people (read: US citizens) were screwed out of their money, when in fact it will be that very crack down that's screwing people over.
I don't think being registered in Belize or some other gray spot on the map will help either, Liberty Reserve was not under US jurisdiction, that didn't stop the world police from doing what they do best: strong-arming others into complying with their vision of justice.