How many coins?  We offer below market prices to large buyers (see sig).

If you need a few coins and need them right now, BitInstant is likely your easiest and most direct option.

If you want to use an exchange check out bitfloor.

I'm watching the IPO with great interest, but I'm not going anywhere near it personally - seems like a good way to get on the wrong list.

If you have more than 1000 Bitcoins in your wallet:

1. get yourself a low cost netbook.
2. Install not bloated linux (like archlinux) or FreeBSD or OpenBSD (in order of growing paranoia).
   - make sure that the above is done with ecrypted partitions and swap (plenty of guides on the net).
   - make sure that the above is done while offline as much as possible (for truly paranoid ones).
   - make sure that you do not not even configure wireless hardware, let alone using it
   - physically plug in Ethernet cable when you need connectivity for a minute or so
3. Install bitcoin client, generate a bunch of bitcoin addresses (current account)
4. Over time transfer in small amounts your funds from your existing client to the addresses created in step 3
5. Keep this used exclusively as bitcoin client and nothing else, plug in Ethernet cable when you need to transfer money.
6. Keep this hardware wallet safe.
7. Creating a bitcoin savings account and making secure backups is still need to be done as described in multiply guides elsewhere.

P.S. Do not forget your passwords.

that's how it's on the internet. Ignore it and move on.