of course. not every driver is good for every cards. if you compile kernel on wrong drivers you will got bad results. you can see my results in some older posts.
18.3.3 compute mode == blockchain driver == good result 0.42 CPD for RX 580 1250 MHz
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Topic
BoardMining (Altcoins)
Re: Open Source XPM (Primecoin) GPU Miner & Pool xpmforall.org