In my opinion, (Well, this is the difference of taste I think) the safest way to save your Bitcoin, is to use hardware wallets like Ledger and Trezor. With a hardware wallet, you will always need this hardware to access your Bitcoin, making it more secure. And you also have to give physical approval to do the transaction. This feature can improve security because if a hacker attacks your computer, the hacker will not be able to physically press the lock on your hardware to give transaction approval.